Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Are they suitable for compression? Bilateral cellulitis is uncommon.

Leg Ulcers and recurrent cellulitis –

In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped. Prophalactic antibiotics for the prevention of cellulitis erysipelas of the leg: Is it chronic changes of venous stasis and chronic ulceration?

We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only. Comment in N Engl J Med. Antibiotics do not improve healing unless active infection. Doses are oral and for adults unless otherwise stated.


Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy. The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group.

Penicillin to prevent recurrent leg cellulitis.

We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland.

Comments from Expert Advisory Committee Cellulitie do not improve healing unless active infection. A total of patients were recruited. Statins can interact cdllulitis some antibiotics and increase the risk of rhabdomyolysis. Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs. The primary outcome was the time to a first recurrence.


Participants were followed for up to 3 years. Please refer to our Drug Interactions Table for further information.

Amiodarone and drugs which prolong the QT interval can interact with many antibiotics. Review antibiotics after culture results.

Refer for specialist opinion if severe infection Is it cellulitis? Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. Colonisation is likely in leg ulcers. Leg Ulcers and recurrent cellulitis. Many antibiotics increase the risk of bleeding with anticoagulants.

Penecillin to prevent leg cellulitis NEJM ; Skip to main content. N Engl J Med. Baseline characteristics were similar in the two groups.